NCT03409380

Supplementation Trial on Arginine With Metabolic Profiling

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Pennington Biomedical Research Center · Academic / Other
• Sex: Male
• Age: 18 Years – 39 Years
• Healthy volunteers: Accepted

Summary

This study will assess effects of an acute dose of the amino acid arginine on metabolism in healthy young men.

Detailed description

A double - blind randomized, crossover design trial examining arginine vs. placebo beverage treatments will be performed. The primary objective is to determine the effects of arginine assessed by standard laboratory assays and metabolomics. To accomplish the objective standardized meals will be provided for 2 days preceding treatment for dietary consistency. Participants will arrive at the center following a 10-12 hr fast. Blood samples will be collected at baseline (fasting), 1.5 hrs, 3.0 hrs, 6.0 hrs, and 24 hrs post treatment. Plasma prolactin, growth hormone, amino acids, glucose, insulin, triacylglycerols, thyroid hormones (TSH, T3, and T4), sex hormone binding globulin (SHBH), testosterone, cortisol, DHEA, and citrulline will be measured. Metabolomics will be measured at 3 time points for each treatment. Peripheral arterial tonometry (PAT) will also be performed at \~2 hrs following treatment to examine endothelial function in response to nitrous oxide release. In addition, psychological status including fatigue will be assessed using a standardized mood questionnaire (POMS).

Conditions

• Protein
• Amino Acid
• Arginine

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Arginine Drink	10 g of arginine in a formulated drink
DIETARY_SUPPLEMENT	Plain Drink	formulated drink

Timeline

• Start date: 2018-02-08
• Primary completion: 2019-07-08
• Completion: 2019-07-08
• First posted: 2018-01-24
• Last updated: 2022-09-14

Locations

1 site across 1 country: United States