NCT03408457

Influence of Perioperative Fluid Balance on Serum Concentrations of Antibiotics and Surgical Site Infections

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 130 (actual)
• Sponsor: Johannes Gutenberg University Mainz · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

This study evaluates antibiotic serum concentrations in correlation with perioperative fluid balance. Patients will be recruited in rectum and esophageal surgery (representative for low blood loss and restrictive fluid management) and in liver surgery (representative for high blood loss and liberal fluid management). The hypothesis is that high blood loss and liberal fluid management dilute antibiotic serum concentrations thereby potentially increasing surgical site infections.

Conditions

• Antibiotic
• Anti-Bacterial Agents
• Surgical Wound Infection

Interventions

Type	Name	Description
PROCEDURE	Blood sampling after antibiotic administration	Sampling of 6 x 8 mL (in sum 48 mL) via the central venous line (established for the surgical procedure) until postoperative day 2

Timeline

• Start date: 2018-03-14
• Primary completion: 2019-04-04
• Completion: 2019-05-14
• First posted: 2018-01-24
• Last updated: 2019-05-30

Locations

1 site across 1 country: Germany