NCT03408379

Impact of Platelet Activation in Intracranial Aneurysm Rupture Risk - PLAQRAN

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 230 (actual)
• Sponsor: Fondation Ophtalmologique Adolphe de Rothschild · Network
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Sub arachnoid hemorrhage consecutive to intracranial aneurysm rupture is a devastating disease. Predictors of intracranial aneurysm rupture are limited and focus mainly on size and location. Platelet activation may have a deleterious role on aneurysm rupture. The assumption is that patients with ruptured intracranial aneurysm will present a higher rate of platelet activation compared to patients with non ruptured aneurysms.

Conditions

• Intracranial Aneurysms
• Ruptured Aneurysm

Interventions

Type	Name	Description
OTHER	Collection of blood sample in aneurysm	In case of an endovascular treatment : * A blood sample (venous or arterial) of 10 ml will be taken at the beginning of the procedure, an intra aneurysmal blood sample (1mL) will be taken during the procedure and a blood sample (arterial) of 1 mL will be taken at the end of the procedure. * Iterative blood samples (arterial) of 10 mL will be taken at each follow up visit. In case of a surgery treatment : * A blood sample (venous or arterial) of 10 ml will be taken at the beginning of the surgery. * A Tissue sample will be taken during the surgery * Iterative blood samples (arterial) of 10 mL will be taken at each follow up visit.

Timeline

• Start date: 2017-12-20
• Primary completion: 2032-06-23
• Completion: 2033-06-23
• First posted: 2018-01-24
• Last updated: 2026-01-20

Locations

1 site across 1 country: France