NCT03408275

Dietry Pattern and Lead Levels in Pregnancy

Dietary Patterns and Variability in Blood Lead Concentrations Among Pregnant British Women

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 2,167 (actual)
• Sponsor: University of Bristol · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Accepted

Summary

During pregnancy lead crosses the placenta freely and can have adverse effects on the fetus, with the potential for life-long impact on the child. Identification of dietary patterns and food groups in pregnancy in relation to measures of lead status could provide a more useful alternative to a nutrient-specific advice to minimise fetal exposure to lead during pregnancy. The aim is to evaluate whether dietary patterns and food groups are associated with blood lead concentrations in pregnancy.

Detailed description

Whole blood samples were collected from pregnant women enrolled in the Avon Longitudinal Study of Parents and Children observational birth cohort study and were analysed for lead. Dietary pattern scores were derived from principal components analysis of a food frequency questionnaire. Associations of quartiles of dietary pattern scores, and of food groups categorised by frequency of consumption, with the likelihood of blood lead concentration (B-Pb) ≥5 µg/dl will be identified with adjusted logistic regression (n=2167).

Conditions

• Dietary Habits
• Lead Poisoning
• Pregnancy Related

Interventions

Type	Name	Description
OTHER	None - observational	None - observational

Timeline

• Start date: 1991-04-01
• Primary completion: 1992-12-01
• Completion: 1992-12-01
• First posted: 2018-01-23
• Last updated: 2018-01-23