NCT03408158

HPA Antibodies and the Distribution of Antigen and Antibodies

Multi-center Study in the Frequency of HPA Antibodies and the Distribution of Antigen and Antibodies in Chinese Blood Disease Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 6,170 (actual)
• Sponsor: Guangzhou First People's Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

By detecting platelet antibodies of participants and then further to identify their genotype and analyzing laboratory examination, the investigators will obtain positive frequency of HPA antibodies, the distribution of HPA antigen and antibodies, effect of matching platelet transfusion, all of which in favor of draw a conclusion that it is very important to carry out HPA antibody detection and matching transfusion in early phase.

Detailed description

1. The investigators will detect platelet antibodies of participants who are according with the inclusive criteria. 2. For participants with platelet antibodies, the investigators should screen out cases owning HPA antibodies and further to identify their genotype. 3. Platelet infusion of same type will be applied to half of participants with HPA antibodies as experimental group, and the another half of participants with hematopathy will be infused ordinary platelets as control. The investigators will estimate the effect of matching transfusion through laboratory examination such as platelet count 1 hour and 24 hours after transfusion and clinical feature comparing to control group. 4. Finally, the investigators will obtain several conclusions includes positive frequency of HPA antibodies, the distribution of HPA antigen and antibodies, effect of matching platelet transfusion by analyzing a bunch of relevant information. So, strong evidence will be provide to decide if it is very important to carry out HPA antibody detection and matching transfusion in early phase.

Conditions

• Blood Disease
• Platelet Refractoriness
• Antibody-mediated Rejection

Interventions

Type	Name	Description
PROCEDURE	same type infusion of main HPA antigen	Compare the differences of platelet count between participants with same type infusion of main HPA antigen and not

Timeline

• Start date: 2017-01-01
• Primary completion: 2020-12-31
• Completion: 2020-12-31
• First posted: 2018-01-23
• Last updated: 2021-08-12

Locations

1 site across 1 country: China