NCT03406676

Pre-treatment With Methylene Blue Prevent Peri-operative Reduced Systemic Vascular Resistance

The Preventive Effects of Pre-treatment With Methylene Blue for Vascular Paralysis of the Patients With Obstructive Jaundice During Operation

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: Southwest Hospital, China · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

To explore the effects of pre-treatment with methylene blue on reduced perioperative vascular resistance in patients with obstructive jaundice.

Detailed description

Hemodynamic characteristics of patients with obstructive jaundice are high cardiac output, low peripheral vascular resistance. The molecular basis for this feature is the increased production of NO. Methylene blue can increase peripheral resistance, the mechanism is: methylene blue is an oxidoreductase inhibitor, can inhibit the increased production of NO in the vascular endothelium, thereby increasing peripheral vascular resistance.

Conditions

• Obstructive Jaundice

Interventions

Type	Name	Description
DRUG	Methylene Blue	2mg / Kg of methylene blue in volume of 50ml is administrated I.V before anesthesia induction.

Timeline

• Start date: 2017-08-01
• Primary completion: 2018-10-30
• Completion: 2018-10-30
• First posted: 2018-01-23
• Last updated: 2018-01-23

Locations

2 sites across 1 country: China