NCT03405805

Immunological Memory Against Pneumococcus Induced by 3 Infant PCV 13 Vaccination Schedules

The Establishment of Serotype-specific Immunological Memory Against Pneumococcus by a 3+1 Versus a 2+1 or 3+0 Infant PCV13 Vaccination Schedule

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Aghia Sophia Children's Hospital of Athens · Academic / Other
• Sex: All
• Age: 2 Months – 15 Months
• Healthy volunteers: Accepted

Summary

The purpose of this study is to evaluate the establishment of immunological memory between the 3 different infant vaccination schedules with the 13-valent pneumococcal conjugate vaccine (PCV13) currently in use. We aim to determine the optimal schedule for the establishment of antigen-specific memory B-cell pool, which may serve as a correlate for longevity of immunological memory against vaccine serotypes. Moreover, we will study the transcriptome profiles expressed by peripheral lymphocytes during each immune response in an attempt to reveal immunological mechanisms beyond the antibody and circulating B cells level.

Conditions

• Immunogenicity, Vaccine
• Immunologic Memory

Interventions

Type	Name	Description
BIOLOGICAL	13-valent pneumococcal conjugate vaccine (PCV13)	Vaccination with PCV13

Timeline

• Start date: 2016-12-12
• Primary completion: 2018-12-01
• Completion: 2019-12-01
• First posted: 2018-01-23
• Last updated: 2018-01-23

Locations

1 site across 1 country: Greece