NCT03404037

Serum Endostatin Type 2 Diabetic Patients

Serum Endostatin Level as a Marker for Coronary Artery Calcification in Type 2 Diabetic Patients With Coronary Heart Disease

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 110 (actual)
• Sponsor: Zagazig University · Other Government
• Sex: All
• Age: 50 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

To assess the relationship between serum endostatin (ES) and Coronary artery calcification (CAC) in type 2 diabetic (T2DM) patients.

Detailed description

elevated serum endostatin levels were independently associated with increased risk, severity and progression of coronary artery calcification independent of traditional cardiovascular disease risk factors in T2DM subjects with known coronary artery disease. So, Measurement of serum ES levels can improve the diagnosis of coronary artery calcification and could be useful as a high sensitive marker for the presence and progression of atherosclerosis in T2DM patients.

Conditions

• Diabetes Mellitus, Type 2
• Coronary Artery Disease
• Coronary Arteriosclerosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	serum endostatin level	An oral (metoprolol 20 mg) was given to the patients with heart rates \> 60 beats/minute and had no contraindications to beta-blockers, one hour before the scan. Sublingual nitroglycerin was given to all patients before CT examination. A 64-slice CT scanner (Sensation 64; Siemens Medical System, Germany) was used for imaging all subjects. All CT examinations were done during inspiratory breath holding. Endostatin levels were measured using a sandwich ELISA kit according to the manufacturer's instructions endostatin ELISA kit (R\&D Systems, Minneapolis, Minnesota, USA

Timeline

• Start date: 2017-03-02
• Primary completion: 2017-11-11
• Completion: 2017-12-20
• First posted: 2018-01-19
• Last updated: 2018-01-19

Locations

1 site across 1 country: Egypt