NCT03403842

Acute Post-operative Pain in Colon Resections

Treatment of Acute Post-operative Pain in Patients Undergoing Laparoscopic Colon Resections

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 159 (estimated)
• Sponsor: IRCCS San Raffaele · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

Objective of the study is to compare three different analgesic techniques in patients undergoing laparoscopic colon resections: peridural catheter, patient controlled analgesia of endovenous morphine and patient controlled analgesia of sufentanil sublingual tablets.

Detailed description

159 patients undergoing laparoscopic colon resections will be enrolled and randomized in three different groups. Patients in the first group will be subjected to the positioning of a peridural catheter with a continuous infusion of ropivacaine 0,2%99 ml+sufentanil 50 mcg at an infusion rate of 4-6 ml/h. In the second group participants will receive an intraoperative bolus of morphine (0,05mg/kg) and post-operatively a patient controlled analgesia of endovenous morphine (injection dose 1 mg,lock-out 10 minutes,maximum morphine dosage for hour 4 mg). In the third group the investigators will adopt an intraoperative bouls of morphine (0,05mg/kg) and post-operatively a patient controlled analgesia of sufentanil sublingual tablets( 15 mcg, lock-out 20 minutes)

Conditions

• Analgesia

Interventions

Type	Name	Description
DEVICE	Sublingual sufentanil tablet system	Administration of sublingual sufentanil with a PCA
DEVICE	Peridural catheter	Positioning of a peridural catheter with a continuous infusion of ropivacaine 0,2% 99 ml+sufentanil 50 mcg
DRUG	PCA Morphine	Administration of endovenous morphine with a PCA

Timeline

• Start date: 2018-02-01
• Primary completion: 2019-08-01
• Completion: 2019-08-01
• First posted: 2018-01-19
• Last updated: 2019-02-07

Locations

1 site across 1 country: Italy