Trials / Completed
CompletedNCT03403647
Effect of Vitamin D on Everolimus Trough Concentrations Among Heart Transplanted Patients
The Effect of Normalizing Vitamin D Concentrations on Everlomius Trough Concentrations
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 11 (actual)
- Sponsor
- Sheba Medical Center · Other Government
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Vitamin D is part of the regular treatment regimen among patients after heart transplantation. Due to potential drug-drug interaction between vitamin D and everolmus, these patients are in increased risk for increased everolimus metabolism, potentially leading to under- immunosupression.
Detailed description
post heart transplantation patients treated with everolimus will be screened for vitamin D levels. Patients defined as deficient will be treated with vitamin D with close and intensive monitoring everolimus levels, adjusting oral daily dose to maintain therapeutic levels.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIETARY_SUPPLEMENT | Vitamin D | Oral daily vitamin D |
Timeline
- Start date
- 2018-07-15
- Primary completion
- 2019-04-10
- Completion
- 2019-04-10
- First posted
- 2018-01-18
- Last updated
- 2019-04-18
Locations
1 site across 1 country: Israel
Source: ClinicalTrials.gov record NCT03403647. Inclusion in this directory is not an endorsement.