NCT03402113

Sedation Protocols and Skeletal Muscle Metabolism in Mechanical Ventilated Patients

The Effect of Different Sedation Protocols on Skeletal Muscle Metabolism in Mechanical Ventilated Patients

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 360 (estimated)
• Sponsor: Chinese Medical Association · Network
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

To investigate the effects of different sedation protocols on skeletal muscle metabolism in mechanical ventilated patients in ICU. Mechanical ventilated patients who are anticipated to stay in ICU for more than 5 days are enrolled and randomly assigned to the following three groups, interventional group(dexmedetomidine), control group(midazolam) and no sedation group. Serum, CT scan of intercostal muscles, ultrasound evaluation of quadriceps femoris are obtained.

Conditions

• Hypercatabolism
• Sedative, Hypnotic, or Anxiolytic Use Disorders

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	consistent infusion at a loading dose of 0.15ug/kg/h, increased by 0.15ug/kg/h, with a maximum dose of 1.5ug/kg/h.
DRUG	Midazolam	consistent infusion at a loading dose of 1mg/h, increased by 1mg/h, with a maximum dose of 10mg/h.

Timeline

• Start date: 2017-12-20
• Primary completion: 2018-10-31
• Completion: 2019-01-31
• First posted: 2018-01-18
• Last updated: 2018-03-29

Locations

1 site across 1 country: China