NCT03401892

Retinal Neuro-vascular Coupling in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 1 (actual)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Ischemic optic neuropathy is among the most common causes of serious impaired vision in the middle-aged and elderly population in the western world. The current study focuses on a subgroup of ischemic optic neuropathy, the so-called non-arteritic ischemic optic neuropathy (NAION). Although the exact pathogenesis of NAION has not been fully clarified it is known that patients with cardio-vascular risk factors such as hypertension, diabetes mellitus and dyslipidemia have also an increased risk to develop NAION. Along this line of thought it has been shown that patients with a history of NAION in one eye have an increased risk to develop NAION also on the contralateral eye. However, clinical studies investigating ocular perfusion abnormalities in patients with NAION are sparse and even contradicting. Thus, the current study seeks to measure ocular blood flow parameters in patients with a history of NAION and compare it to healthy age-matched subjects.

Conditions

• Anterior Ischemic Optic Neuropathy

Interventions

Type	Name	Description
DEVICE	Dynamic Vessel Analyzer (DVA)	Retinal vessel diameters and oxygen saturation will be measured with the DVA device.
DEVICE	Fourier Domain Doppler Optical Coherence Tomography (FDOCT)	Retinal blood flow will be assessed using FDOCT.
DEVICE	Optical coherence tomography (OCT)	Nerve fiber layer thickness and central retinal thickness will be measured using OCT.

Timeline

• Start date: 2018-06-11
• Primary completion: 2018-06-11
• Completion: 2018-06-11
• First posted: 2018-01-17
• Last updated: 2021-09-01

Locations

1 site across 1 country: Austria