NCT03401177

Treatment of Early Phase Achilles Tendinopathy - the Effect of NSAIDs

The Effect of NSAIDs in the Early Phase of Achilles Tendinopathy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: Bispebjerg Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

this study evaluates the addition of initial short term NSAID treatment to physiotherapy prescribed exercise treatment in patient with early phase tendinopathy. Half of the participants will initially receive NSAID (naproxen) for 7 days, while the other half will receive a placebo, where after both groups will be subjected to 3 months heavy slow resistance training.

Detailed description

NSAID is effective in short term pain relief in musculoskeletal disorders, but little is known about the long-term effect in early phase tendinopathy, when used as a supplement to treatment as usual, namely heavy slow resistance training and training load reduction. In this study, NSAIDs will be used, which works through COX inhibition, which again inhibits Prostaglandins, in this way investigators attempt to dampen the initial inflammation and pronounced cell activity that is thought to be present in early phase tendinopathy. With this project, it will be attempted to investigate whether initial dampening adds to the effect achieved through heavy load resistance training, which is thought to stimulate structural repair and regeneration in the tendon, by applying appropriate load to the tendon tissue, thereby stimulating the tendon cells to repair and regeneration.

Conditions

• Tendon Injuries
• Achilles Tendinopathy
• Inflammation

Interventions

Type	Name	Description
DRUG	Naproxen 500 Mg	Naproxen is used as a tool to dampen the inflammation thought to be present in early phase Tendinopathy
DRUG	Placebo Oral Tablet	Placebo is used, to provide a control to the active group.
OTHER	Heavy resistance training	Heavy slow resistance training - used in both groups subsequent to the initial week of NSAID or placebo treatment.

Timeline

• Start date: 2018-01-15
• Primary completion: 2019-07-31
• Completion: 2020-04-27
• First posted: 2018-01-17
• Last updated: 2020-07-09

Locations

1 site across 1 country: Denmark