NCT03400696

Web-based Weight Loss Intervention

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 63,656 (actual)
• Sponsor: 23andMe, Inc. · Industry
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Excess weight is a major risk factor underlying leading causes of death globally, including cardiovascular disease, type 2 diabetes, and some cancers. Among participants assigned to the same lifestyle intervention arms in prior weight loss randomized controlled trials, large inter-individual differences in weight loss success have been observed, ranging from \>50lbs of weight loss to \>10lbs of weight gain. Both genetic and non-genetic factors underlying differential adherence and weight loss success are poorly understood.

Detailed description

23andMe aims to recruit 91,227 adults to participate in a web-based weight loss intervention. Primary aims include: a.) to confirm whether AG/GG individuals at MTIF3 rs1885988 lose more weight on lifestyle interventions; and b.) to test the performance of a randomized controlled trial vs. self-selection study design in terms of weight loss, drop-outs, and adherence. Secondary (exploratory) analyses will focus on discovery of genetic and non-genetic predictors of weight loss success overall, and examination of potential interactions by intervention type. Web-administered intervention content, videos, and forums will be surfaced to participants every two weeks, and self-reported surveys will be surfaced weekly for the active intervention duration.

Conditions

• Overweight and Obesity

Interventions

Type	Name	Description
BEHAVIORAL	Lower carbohydrate diet	Focused on limiting dietary carbohydrates, eating healthy fat and protein sources, and engaging in physical activity
BEHAVIORAL	Higher fiber diet	Focused on increasing dietary fiber, lowering fat intake from animal sources, and engaging in physical activity
BEHAVIORAL	Physical activity focused	Focused on aerobic and resistance exercise, while following dietary guidelines \<https://www.choosemyplate.gov\>

Timeline

• Start date: 2017-12-27
• Primary completion: 2019-01-08
• Completion: 2019-04-16
• First posted: 2018-01-17
• Last updated: 2020-06-04

Locations

2 sites across 1 country: United States