NCT03400137

IOP Elevation Study

Effects of Elevated Intraocular Pressure on the Lamina Cribrosa

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: NYU Langone Health · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to improve understanding of the pathophysiologic process that leads to the development of glaucamotous damage. The mechanism by which vision loss in glaucoma occurs is still unknown, but it is clear that increased intraocular pressure (IOP) is a major risk factor. It is also thought that the LC is a site of primary damage during pathogenesis of the disease. This prospective study with determine the in-vivo mechanical response to IOP modulation at the level of the ONH and LC.

Detailed description

The present study will briefly increase the pressure in eyes of living subjects and examine the effect of elevated intraocular pressure on optic nerve topography and position during pressure elevation using optical coherence tomography imaging of the posterior eye. Outcome measures will include measurements in microns based on these images quantifying the deformation of the lamina cribrosa.

Conditions

• Intraocular Pressure

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Increasing of intraocular pressure (IC)	intraocular pressure will be increased using an ophthalmodynanometer

Timeline

• Start date: 2018-03-07
• Primary completion: 2024-05-08
• Completion: 2024-05-08
• First posted: 2018-01-17
• Last updated: 2023-08-31

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study