NCT03398811

Abnormal Uterine Bleeding and Progestin-only Contraceptives

Predictors of Abnormal Uterine Bleeding in Progestin-only Contraceptives Users

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 390 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

The use of progestin-only methods of contraception has been increased obviously and progressively over the world in the last few years. Progestin-only contraception is an option for women in whom an estrogen-containing contraceptive is either contraindicated or causes additional health concerns. Progestogen-only pills are contraceptive pills that contain only synthetic progestogens (progestins) and do not contain estrogen . The progestin-only pill is recommended over regular birth control pills for women who are breastfeeding because the mini-pill does not affect milk production. The most common progestin-only method used is the injectable depot medroxy-progesterone acetate which had been approved by Food and Drug Administration since 1992 . depot medroxy-progesterone acetate provides reliable, private, long-acting (three months) and reversible contraception. Users of depot medroxy-progesterone acetate don't need daily taking as well as it doesn't affect the intercourse by any mean. The etonogestrel implant (Implanon) is a single-rod progestin contraceptive method placed subdermally in the inner aspect of upper non dependant arm for three years. Much evidence supports the safety, efficacy, reversibility and acceptability of this contraceptive method. A common reason women choose to discontinue progestin-only contraception is dissatisfaction with its effects on uterine bleeding which occurs in a significant number of users. Information revealed from many clinical trials shows that abnormal uterine bleeding with progestin-only contraception ranging from 10 to 25 % at first year of use.

Conditions

• Contraception

Interventions

Type	Name	Description
DRUG	Depot medroxy-progesterone acetate	Injection every 3 months
DRUG	Etonogestrel	68 mg implant
DRUG	Desogestrel 75 µg	one pill every day for 28 days without pill-free interval.

Timeline

• Start date: 2018-08-01
• Primary completion: 2020-08-01
• Completion: 2020-11-01
• First posted: 2018-01-12
• Last updated: 2020-12-17

Locations

1 site across 1 country: Egypt