NCT03397992

Low Dialysate Temperature During SLED

Low Dialysate Temperature to Prevent Intradialytic Hypotension During SLED in AKI

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 38 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Objectives: This study is evaluating the hemodynamic effects of lowering the dialysate temperature in acute kidney injury (AKI) patients submitted to sustained low efficiency dialysis (SLED) in a single large center. Methods: Participants will be randomly assigned to two treatment groups. One group will be started treatment with low temperature (set point 5 on the machine which is around 35°C) for one treatment and then alternate between high and low temperatures for a maximum of 8 treatments. The other group will be started with high temperature (set point 9 on the machine which is around 37°C) for the first treatment then alternate between high and low temperatures for a maximum of 8 treatments. Each participants will need at least two treatments, one with each temperature to be included in the analysis. The investigators will be looking for the number of events during a SLED treatment. Events will be defined as drop in systolic blood pressure ≥ 20 mmHg or drop in mean arterial pressure (MAP) of ≥10 mmHg, requirement of resuscitation with IVF after initiation of SLED, initiation or increase requirement of vasoactive drugs.

Conditions

• Acute Kidney Injury
• Intra-dialytic Hypotension

Interventions

Type	Name	Description
OTHER	Changing dialysate temperature	Patients had SLED with low dialysate temperature (around 35°C) compared with high dialysate temperature (around 37°C)

Timeline

• Start date: 2017-01-16
• Primary completion: 2017-04-22
• Completion: 2017-04-22
• First posted: 2018-01-12
• Last updated: 2018-01-12