NCT03397810

Effect of Radiotherapy on ATTR Cardiac Amyloidosis : a Proof of Concept Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (estimated)
• Sponsor: Philippe Meyer · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

Cardiac amyloidosis is responsible for significant morbidity associated with heart failure, and carries a poor prognosis. Currently there are very limited treatment options for this condition. Radiotherapy has been used successfully to treat amyloidosis elsewhere in the body, however has not been tried in cardiac amyloidosis. Therefore this study aims to assess the effect of radiotherapy on cardiac amyloidosis, to evaluate whether it can successfully reduce the burden of amyloid deposits in the myocardium as assessed by 18F-Amyloid PET.

Detailed description

The intervention will involve administration of external beam radiotherapy (5 fractions of 2Gy) focused to the heart. Measurements of effect will be assessed at 12 weeks by: Amyloid PET Cardiac MRI with administration of gadolinium and ultrasound A blood venous sample (cardiac biomarkers) Quality of life assessments

Conditions

• Amyloid Cardiomyopathy

Interventions

Type	Name	Description
RADIATION	low dose radiotherapy	10 Gy in 5 fractions of 2 Gy on 5 consecutive days

Timeline

• Start date: 2019-03-15
• Primary completion: 2026-02-28
• Completion: 2026-02-28
• First posted: 2018-01-12
• Last updated: 2021-05-11

Locations

1 site across 1 country: Switzerland