NCT03396523

Losartan and Emotion Processing

Losartan Effects on the Extinction of Conditioned Fear in Humans

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: University of Electronic Science and Technology of China · Academic / Other
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is to investigate the effect of losartan (50mg, single dose) on the extinction of conditioned fear

Detailed description

In a double-blind, between-subject, placebo controlled design the effects of a single dose of losartan (50mg) on fear extinction in healthy male participants will be examined. Participants will initially undergo a Pavlovian fear conditioning procedure, followed by the administration of 50mg losartan or placebo. 90 minutes after treatment subjects will undergo the fear extinction procedure. Neural activity and psychophysiological indices of arousal will be assessed by the simultaneous acquisition of functional magnetic resonance imaging (fMRI) and skin conductance data.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Losartan	administration of losartan (50 mg) (oral)
DRUG	Placebo Oral Tablet	administration of placebo (oral)

Timeline

• Start date: 2018-01-04
• Primary completion: 2018-10-31
• Completion: 2018-12-31
• First posted: 2018-01-11
• Last updated: 2018-06-06

Locations

1 site across 1 country: China