NCT03393728

Heart Rate Variability and Hyperthyroidism: Evaluation of the Short-term Effects of Propanolol

Short Term Effects of Propanolol on Heart Rate Variability of Hyperthyroidism

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Yaounde Central Hospital · Other Government
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Objective: The aim of our study was to evaluate the short term effects of Propanolol on heart rate variability in patients with hyperthyroidism. Design: In ten patients newly diagnosed as having hyperthyroidism and naïve of all treatment specific for hyperthyroidism, we evaluated the short term effects of Propanolol on heart rate variability (HRV). Methods: We measured heart rate variability by power spectral analysis during 2 hours of rest and during Ewing's tests before and after the administration of Propanolol 40mg/12 hours orally for 72 hours.

Detailed description

Objective: The aim of our study was to evaluate the short term effects of Propanolol on heart rate variability in patients with hyperthyroidism. Design: In ten patients newly diagnosed as having hyperthyroidism and naïve of all treatment specific for hyperthyroidism, we evaluated the short term effects of Propanolol on heart rate variability (HRV). Methods: We measured heart rate variability by power spectral analysis during 2 hours of rest and during Ewing's tests before and after the administration of Propanolol 40mg/12 hours orally for 72 hours. Other outcomes included mean heart rate, mean R-R interval during 2-hour rest. The study questions the systematic adjunction of Propanolol early in the treatment of hyperthyroidism.

Conditions

• Hyperthyroidism

Interventions

Type	Name	Description
DRUG	Propanolol	72-hour propanolol before specific treatment of hyperthyroidism

Timeline

• Start date: 2008-09-01
• Primary completion: 2008-12-30
• Completion: 2009-09-30
• First posted: 2018-01-08
• Last updated: 2018-01-08