NCT03391245

Vitamin D Level and Risk of Infections in Cirrhotic Patients

Vitamin D Level and Risk of Infections in Cirrhotic Patients: Does it Have a Role?

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 87 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

It is widely known that vitamin D has an important role in calcium metabolism and bone mineralization. Its deficiency is related to rickets and osteomalacia in children and adults respectively. Vitamin D had a role in innate and acquired immunity. It increases innate defense and modulates lymphocytes activation, leading to a change toward a T2 helper response ). The role of vitamin D deficiency on the risk of bacterial infection among patients in intensive care units has been reported. An observational studies in children reported an association between low 25-OH vitamin D level and infectious viral diseases . The deranged metabolism of vitamin D in liver cirrhosis was first reported in the late '70s and was attributed mainly to impaired 25(OH)-vitamin D hydroxylation of the precursor vitamin D caused by impaired liver function. Low level of vitamin D was found independently to be associated with increased risk of bacterial infections in patients with liver cirrhosis. The observed relationship between the lack of vitamin D and the increase risk of mortality in cirrhotic patients could be attributed to bacterial infections. Thus, the association of low vitamin D levels with liver insufficiency and infections supports the use of vitamin D as a prognostic marker in the population of cirrhosis. Studies on the role of vitamin D as a risk factor for infections in patients with liver cirrhosis are not well studied in our locality(Upper Egypt).

Conditions

• Vitamin D Deficiency
• Infection
• Liver Cirrhosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	3- Serum 25-Hydroxy Vitamin D level will be measured by Competitive ELISA technique	Serum 25-Hydroxy Vitamin D level will be measured by Competitive ELISA technique using CALBIOTECH (A life science company) kit, Catalog No.: VD220B

Timeline

• Start date: 2017-08-01
• Primary completion: 2018-01-15
• Completion: 2018-02-15
• First posted: 2018-01-05
• Last updated: 2018-01-08

Locations

1 site across 1 country: Egypt