NCT03389022

Ketamine for Postoperative Pain in Bariatric Surgery

The Effects of Ketamine on Postoperative Pain After Intraoperative Remifentanil Infusions in Bariatric Surgery

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 64 (estimated)
• Sponsor: Lithuanian University of Health Sciences · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study was to evaluate an effect of pre - incisional single injection of low-dose ketamine on postoperative pain after remifentanil infusion in patients undergoing laparoscopic gastric bypass and gastric plication surgery. Ketamine is an old general anaesthetic. Low doses of it might be used as a adjunct in postoperative analgesia.The investigators expect that the low-dose ketamine reduces postoperative pain after bariatric surgeries.

Detailed description

Effective postoperative pain management enhances early postoperative rehabilitation and may improve outcomes of surgical treatment. New analgetic medications and combinations of these are sought for optimal analgesia with lowest possible incidence of side effects. One of the method of multimodal analgesia is a combination of opioids and adjuvant agents, such as ketamine. To our knowledge, the role of ketamine in the treatment of postoperative pain after bariatric surgeries is poorly researched. The investigators hypothesize that ketamine, acting through the N-methyl-D-aspartate receptor (NMDA) and opioid receptors, provides favourable conditions for adequate post-operative pain management.

Conditions

• Pain, Postoperative
• Bariatric Surgery Candidate

Interventions

Type	Name	Description
DRUG	Ketamine	0,15 mg/kg pre-incisional single bolus dose of ketamine in the operating room.
DRUG	Saline	Intravenous injection given pre-incisional in the operating room.
DRUG	Ketamine	0,3 mg/kg pre-incisional single bolus dose of ketamine in the operating room.
DRUG	Ketamine	0,15 mg/kg pre-incisional single bolus dose of ketamine, followed by continuous infusion of 1 mg/kg in the operating room.
DRUG	Ketamine	0,3 mg/kg (LBM) of intravenous pre-incisional single bolus injection, followed by continuous infusion of 1mg/kg ketamine given for bariatric patients in the operating room.

Timeline

• Start date: 2015-07-22
• Primary completion: 2017-03-30
• Completion: 2023-06-06
• First posted: 2018-01-03
• Last updated: 2021-11-22