NCT03387644

Pregabalin Premedication for Conscious Sedation

Pregabalin Premedication for Conscious Sedation for Flexible Bronchoscopy: A Randomized Double Blind Controlled Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: Menoufia University · Academic / Other
• Sex: All
• Age: 21 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Conscious sedation is usually required during flexible bronchoscopy. Sedation should be done without causing respiratory depression or loss of consciousness. The present study was designed to evaluate the advantage of pregabalin pre-medication on reducing sedatives and respiratory depression for patients undergoing flexible bronchoscopy with dexmedetomidine and midazolam.

Detailed description

Seventy patients undergoing elective flexible bronchoscopy were randomly divided into two equal groups, 35 patients each. All patients received premedication one hour before the procedure. PG group received 150 mg pregabalin and C group received placebo. All patients sedated to achieve optimum working conditions. Intra-operative respiratory rate and post procedure patients' and pulmonologists' satisfaction were compared in both groups.

Conditions

• Conscious Sedation

Interventions

Type	Name	Description
DRUG	Pregabalin (PG)	Pregabalin 150 mg one hour before the procedure as premedication.
DRUG	Control placebo (C)	Placebo tablets one hour before the procedure as premedication.

Timeline

• Start date: 2015-04-15
• Primary completion: 2016-11-24
• Completion: 2017-05-16
• First posted: 2018-01-02
• Last updated: 2018-01-02