NCT03380338

The Effect of Exercise on Gut Microbiota in Type 2 Diabetic Patients

Lifestyle Intervention in Patients With Diabetes Type 2 and the Association With the Gut Microbiota

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Amsterdam UMC, location VUmc · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

To investigate whether targeted lifestyle intervention (exercise), induces a change in intestinal fecal microbiota related to improved glycemic control and systemic inflammation in patients with DM type 2.

Detailed description

Diet and exercise are the most beneficial lifestyle interventions in patients with diabetes mellitus (DM) type 2, causing an increase in glucose tolerance. One of the mechanisms through which these treatment modalities work might be explained through changes in the gut microbiota. Recent studies show that the chronic inflammatory status causing insulin resistance in DM type 2, is triggered by an increase in circulating bacterial lipopolysaccharide (LPS). Strict lifestyle intervention, such as exercise, so called Diabetes Bootcamp (DB), may manipulate the gut microbiota, reducing circulating LPS, causing an improvement of the insulin-mediated

Conditions

• Type 2 Diabetes Mellitus
• Insulin Sensitivity/Resistance

Interventions

Type	Name	Description
BEHAVIORAL	Combined aerobic and strength exercise

Timeline

• Start date: 2016-05-11
• Primary completion: 2017-06-29
• Completion: 2017-06-29
• First posted: 2017-12-21
• Last updated: 2019-06-03

Locations

1 site across 1 country: Netherlands