NCT03380325

The Effect of Iloprost on Capillary Recruitment and Insulin Sensitivity in Type 2 Diabetes

The Effects of Iloprost Infusion on Capillary Recruitment and Whole-body Glucose Uptake in Type 2 Diabetic Patients - a Cross-over Trial.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Amsterdam UMC, location VUmc · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study examines the effects of iloprost - a stable prostacyclin analogue - on insulin-mediated muscle capillary recruitment and whole-body glucose uptake in a cross-over design.

Detailed description

In type 2 diabetes impaired insulin-mediated muscle perfusion is thought to contribute to reduced whole-body glucose uptake. This study aims to identify iloprost - a stable prostacyclin analogue - as a possible therapeutic option to increase whole-body glucose uptake via enhancement of muscle perfusion. All participants will be subjected to two hyperinsulinemic-euglycemic clamps; one with and one without simultaneous iloprost infusion in a randomized cross-over design. Microvascular blood volume will be measured by means of contrast-enhanced ultrasonography.

Conditions

• Diabetes Mellitus, Type 2
• Insulin Sensitivity/Resistance

Interventions

Type	Name	Description
DRUG	Iloprost infusion	Iloprost is a stable prostacyclin analogue

Timeline

• Start date: 2016-05-11
• Primary completion: 2017-06-29
• Completion: 2017-06-29
• First posted: 2017-12-21
• Last updated: 2019-07-18

Locations

1 site across 1 country: Netherlands