NCT03374592

Volumetric Intensity Modulated Arc Therapy vs. Conventional Radiotherapy for Cancer Pain

A Phase II Randomized Controlled Trial of Volumetric Intensity Modulated Arc Therapy vs. Conventional Radiotherapy for Cancer Pain

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 73 (actual)
• Sponsor: Centre hospitalier de l'Université de Montréal (CHUM) · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

This study compares the use of conventional radiotherapy technique with volumetric intensity-modulated radiotherapy (VMAT) in the treatment of painful cancer metastases. Half of the patients will receive radiotherapy using a conventional technique, while the other half will receive their treatment using a the VMAT technique.

Detailed description

Radiotherapy to painful sites of metastasis can provide pain relief. Side-effects from radiotherapy is dependent on the volume and dose received by normal tissues. Conventional radiotherapy techniques delivers similar doses of radiation to the targeted cancer lesion and the normal tissues along the entrance and exit paths of the radiation. Volumetric intensity-modulated arc therapy (VMAT) is an advanced technique of radiotherapy that spares normal tissues from receiving high-dose irradiation. However, VMAT increases the volume of normal tissues receiving low-dose irradiation. This study aims at comparing the quality of life and side-effect profiles of patients treated by palliative radiotherapy using the conventional technique vs. VMAT.

Conditions

• Neoplasm Metastasis
• Pain
• Radiotherapy Side Effect
• Quality of Life

Interventions

Type	Name	Description
RADIATION	Volumetric Intensity-Modulated Arc Therapy	Advanced radiotherapy technique
RADIATION	Conventional Radiotherapy	Conventional radiotherapy technique

Timeline

• Start date: 2014-07-07
• Primary completion: 2017-12-20
• Completion: 2018-02-21
• First posted: 2017-12-15
• Last updated: 2022-11-16