NCT03374449

Impact of Renin-Angiotensin System Inhibitors Continuation on Outcome After Major Surgery

Impact of Renin-Angiotensin System Inhibitors Continuation on Outcome After Major Surgery : a Multicenter, Prospective, Randomized and Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 2,222 (actual)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

More than 200 million major surgical procedures are performed annually worldwide. Many of these patients have comorbidities including hypertension and/or heart failure. Chronic treatment of hypertension and/or heart failure very often includes a Renin-Angiotensin System (RAS) inhibitor (Angiotensin-Converting Enzyme Inhibitors (ACE-Is) or Angiotensin Receptor Blockers (ARBs). To stop or not to stop these medications before major surgery remain unknown. Data on management of RAS inhibitors before major surgery and anesthesia remain lacking and matter of debate. It is much likely that the strategy regarding management of RAS inhibitors in the peri-operative setting have important impact on peri-operative complications. The lack of evidence leads to conflicting guidelines with respect to RAS inhibitors management before major surgery. While French guidelines are to stop RAS inhibitors patients with hypertension to avoid profound anesthestic-drugs-induced hypotension, international guidelines differ. The American heart association task force states that continuation of RAS inhibitors perioperatively is reasonable (class IIa recommendation,level of evidence: B). The purpose of this study is to determine the prognostic impact of withholding vs continuing ARBs before major non cardiac surgery.

Detailed description

Multicenter, prospective, randomized, pragmatic, parallel-group clinical trial. The inclusion visit takes place between 4 months and no later than 3 days before the surgery visit. * The randomization will be performed by the anesthesiologist Control group : RAS-I discontinuation Experimental group: RAS-I continuation * A prescription for the medication strategy (stopping or pursuing the medication) will be handed to the patient during the anesthesiology consultation. Five follow-up visits are planned * Immediately, one hour after the surgery (Day 0) * Then four follow-up visits are planned on day 1, 2, 7 (or hospital discharge) and 28 days+15 days (43 days maximum) after surgery will be collected data and parameters for study endpoints. End of research visit is the 28 days+15 days (43 days maximum) follow-up visit.

Conditions

• Renin Angiotensin System
• Surgery

Interventions

Type	Name	Description
PROCEDURE	continuation of the RAS-inhibitors	drug intake
PROCEDURE	discontinuation of the RAS-inhibitors	no drug intake

Timeline

• Start date: 2018-02-06
• Primary completion: 2023-12-24
• Completion: 2023-12-24
• First posted: 2017-12-15
• Last updated: 2024-05-22

Locations

1 site across 1 country: France