NCT03373994

Perfusion and Hypoxia Evaluation in Tumors Using 18F-FDG PET/CT

Tumor Perfusion and Hypoxia Evaluation and Comparation in 18F-FDG PET/CT

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Harbin Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Investigators want to use 18F-FDG PET/CT imaging to reflect tumor perfusion and hypoxia.

Detailed description

Perfusion and hypoxia were independent prognositic parameters for tumor patients. Developing a method that can evaluate tumor perfusion and hypoxia noninvasively and conveniently was in urgent need. 18F-FDG PET/CT imaging could reflect tumor hypoxia in 60min balanced imaging was proved and accepted. Moreover, FDG could diffuse out of the vasculature and through cell membranes passively and rapidly due to its lipophilicity, its regional uptake at initial times is expected to reflect tumor perfusion. So, investigators want to use 18F-FDG PET/CT imaging to evaluate tumor perfusion and hypoxia simutaniously，in order to guide the clinical diagnosis and treatment.

Conditions

• Perfusion and Hypoxia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	18F-FDG PET/CT initial-time imaging	18F-FDG intravenous bolus injection after a fasting perid of more than 6 hours, simultaneously,PET/CT imaging using one bed lasting 5 minutes was underwent.
DIAGNOSTIC_TEST	18F-FDG PET/CT balanced-time imaging	18F-FDG intravenous injection after a fasting perid of more than 6 hours. After 60 minutes, PET/CT imaging using 6-7 bed positions each lasting 2 minutes was underwent.

Timeline

• Start date: 2016-11-01
• Primary completion: 2020-12-31
• Completion: 2020-12-31
• First posted: 2017-12-14
• Last updated: 2020-02-21

Locations

1 site across 1 country: China