NCT03373643

Obstructive Sleep Apnea and Non-alcoholic Fatty Liver Disease

Association Between Obstructive Sleep Apnea and Non-alcoholic Fatty Liver Disease Investigated by Liver Biopsy

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: University Hospital, Angers · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Obstructive sleep apnea (OSA) and nonalcoholic fatty liver disease (NAFLD) are frequently encountered in patients with metabolic syndrome (MS). Several data suggest that OSA per se could be a risk factor of liver injury. Most previous studies evaluating the association between OSA severity and the severity of NAFLD used indirect markers of NAFLD including liver imaging or liver injury blood markers or have been performed in morbidly obese patients undergoing intraoperative needle liver biopsy during bariatric surgery. The current study propose to investigate with a full night polysomnography consecutive patients undergoing percutaneous liver biopsy for suspected NAFLD.

Conditions

• Non-alcoholic Fatty Liver Disease
• Sleep Apnea, Obstructive

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	OSA screening	Full night polysomnography

Timeline

• Start date: 2017-12-14
• Primary completion: 2019-12-14
• Completion: 2020-03-14
• First posted: 2017-12-14
• Last updated: 2019-01-16

Locations

1 site across 1 country: France