NCT03372811

Efficacy and Safety of a Botanical Total Coumarin (TC) Cream in Treating Patients With Psoriasis Vulgaris (PLANTCOAT-IIb Trial)

A Double-Blind, Randomized, Placebo-Controlled, Multicenter Phase IIb Clinical Trial (PLANTCOAT-IIb) to Evaluate the Efficacy and Safety of a Botanical Total Coumarin (TC) Cream in Treating Patients With Psoriasis Vulgaris

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 88 (actual)
• Sponsor: Psoriasis Research Institute of Guangzhou · Industry
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

A Double-Blind, Randomized, Placebo-Controlled, Multicenter Phase IIb Clinical Trial to Evaluate the Efficacy and Safety of a Botanical Total Coumarin Cream (TC) in Treating Patients with Psoriasis Vulgaris

Conditions

• Psoriasis Vulgaris
• Topical Administration

Interventions

Type	Name	Description
DRUG	Total coumarin (TC) cream	A well-characterized botanical drug for the topical treatment of psoriasis vulgaris. The drug has been approved by the NMPA in China and has obtained an NDA following multiple clinical trials spanning phases I-III in large cohorts.
DRUG	Vehicle	Vehicle

Timeline

• Start date: 2015-06-11
• Primary completion: 2018-03-14
• Completion: 2018-06-30
• First posted: 2017-12-14
• Last updated: 2026-03-25
• Results posted: 2026-03-12

Locations

2 sites across 1 country: United States

Regulatory

• FDA-regulated drug study