NCT03372447

Megadose of Hydroxocobalamin for the Treatment of Pernicious Anemia

Megadose of Hydroxocobalamin (Vitamin B12) for the Treatment of Pernicious Anemia

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: Hospital Universitario Dr. Jose E. Gonzalez · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Demonstrate the effectiveness of a single dose of a multivitamin complex for the treatment of megaloblastic anemia

Detailed description

The investigators will administrate a single intramuscular dose of hydroxocobalamin 10,000mcg, Thiamin 100mg, Pyridoxine 50mg. To assess response to treatment, a complete blood count (CBC) will be performed weekly during the first month of treatment, after the first month a CBC will be taken monthly for 6 months. Also to confirm the diagnosis and assess response the investigators will measure levels of methylmalonic acid, homocysteine, and hydroxocobalamin at the beginning of the study, 3 and 6 months.

Conditions

• Megaloblastic Anemia Nos
• Pernicious Anemia

Interventions

Type	Name	Description
DRUG	Hydroxocobalamin 10,000mcg, Thiamin 100mg, Pyridoxine 50mg	Single intramuscular dose of hydroxocobalamin 10,000mcg, Thiamin 100mg, Pyridoxine 50mg.

Timeline

• Start date: 2017-12-27
• Primary completion: 2018-12-01
• Completion: 2019-12-01
• First posted: 2017-12-13
• Last updated: 2021-03-08

Locations

1 site across 1 country: Mexico