NCT03369717

Use of Perioperative Antibiotics in Endoscopic Sinus Surgery

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Montefiore Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to determine whether the use of postoperative antibiotics following endoscopic sinus surgery (ESS) decreases postoperative infection rates. This is a multi-institutional prospective study involving Albert Einstein College of Medicine/Montefiore Medical Center, Columbia University Medical Center, Weill Cornell Medical College, Mount Sinai Health System, and New York University Langone Medical Center. The study design will be a multi-institutional prospective randomized controlled trial with parallel random groups assigned to receive postoperative antibiotics or no postoperative antibiotics. The investigators hypothesize that patients who receive postoperative antibiotics will have lower postoperative infection rates and improved postoperative sinonasal symptoms and nasal endoscopy scores.

Conditions

• Chronic Sinus Infection

Interventions

Type	Name	Description
DRUG	Amoxi Clavulanate	Postoperative antibiotics

Timeline

• Start date: 2018-08-01
• Primary completion: 2020-05-07
• Completion: 2020-05-07
• First posted: 2017-12-12
• Last updated: 2025-06-17
• Results posted: 2025-06-17

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study