NCT03369548

CABALA Diet & Health Study

CirculAting Bile Acids as Biomarkers of Metabolic Health - Linking microbiotA, Diet and Health

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 64 (estimated)
• Sponsor: University of Reading · Academic / Other
• Sex: All
• Age: 25 Years – 70 Years
• Healthy volunteers: Accepted

Summary

During digestion of fatty foods, the liver produces a substance called bile which helps with the absorption of fat in the gut (small intestine). Some research studies have shown that friendly bacteria that live in our gut can change the makeup of bile (referred to as bile acids) leading to a lowering of blood cholesterol levels, an important risk factor for developing heart disease. This finding has been found in people who consume diets high in dietary fibers and probiotics that enhance the growth of friendly gut bacteria, and also plant rich foods high in polyphenols (such as apples). At present, very little is known about how the makeup of bile acids can regulate blood cholesterol levels and if their measurement in blood, urine or stool samples can be used as an indicator of human health. The aim of this study is to explore how consumption of foods which enhance the growth of friendly gut bacteria (such as probiotics, prebiotics, and plant rich foods high in polyphenols) can change the makeup of bile acids after 8 weeks. Changes in the bile acids measured in blood and stool samples will then be related to markers of health, such as blood cholesterol, glucose, insulin, vascular health and inflammatory markers.

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	Apple	2 Renetta Canada apples and 2 placebo capsules/ day
OTHER	Oats	40g jumbo rolled oats with semi-skimmed milk and 2 placebo capsules / day
DIETARY_SUPPLEMENT	Lactobacillus reuteri NCIMB 30242	2 probiotic capsules and 40g cornflakes with semi-skimmed milk / day.
OTHER	Cornflakes	40g cornflakes with semi-skimmed milk and 2 placebo capsules/ day.

Timeline

• Start date: 2017-12-04
• Primary completion: 2019-11-30
• Completion: 2019-12-23
• First posted: 2017-12-12
• Last updated: 2018-04-12

Locations

1 site across 1 country: United Kingdom