NCT03369535

Metabonomics to Investigate Effects of Healthy Diets on Blood Pressure: the OmniHeart Study

Urinary Metabolic Phenotyping of Diet-cardiovascular Disease Risk Associations: the OmniHeart Feeding Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 158 (actual)
• Sponsor: University of Kent · Academic / Other
• Sex: All
• Age: 30 Years – 80 Years
• Healthy volunteers: Accepted

Summary

To compare the urinary metabolomes on individuals undergone three different healthy diets--a carbohydrate-rich diet, a protein-rich diet, or a diet rich in unsaturated fat.

Detailed description

BACKGROUND: This study based on the OmniHeart dietary intervention study, a randomized, three period cross-over feeding study that compared the effects on blood pressure and plasma lipids of three DASH-like diets: a carbohydrate-rich (CARB) diet pattern, a rich in protein (PROT) and a rich in unsaturated (MUFA) fat, predominantly monounsaturated fat diet (see full details of OmniHeart dietary intervention https://clinicaltrials.gov/ct2/show/record/NCT00051350). This metabonomic study aims to evaluate the feasibility of identifying individuals showing variation in clinical response to three different healthy diets, with the purpose of reducing cardiovascular disease (CVD) risk, using proton nuclear magnetic resonance (NMR) based metabolic phenotyping approach.

Conditions

• Hypertension

Interventions

Type	Name	Description
OTHER	CARB rich diet	Consumed CARB rich diet for 6 weeks with a washout period of at least 2 weeks before the next intervention
OTHER	MUFA rich diet	Consumed MUFA rich diet for 6 weeks with a washout period of at least 2 weeks before the next intervention
OTHER	PROT rich diet	Consumed PROT rich diet for 6 weeks with a washout period of at least 2 weeks before the next intervention

Timeline

• Start date: 2011-10-01
• Primary completion: 2015-07-31
• Completion: 2017-12-01
• First posted: 2017-12-12
• Last updated: 2017-12-12