NCT03369106

Mechanisms of Disease Severity in Multiple Sclerosis: an Integrative Multimodal Study

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 120 (estimated)
• Sponsor: Institut National de la Santé Et de la Recherche Médicale, France · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will identify a combination of disease severity markers (genetic, immunology, epigenetic, imaging) associated with disease severity and progression in a cohort of patients with multiple sclerosis.

Detailed description

The heterogeneity of multiple sclerosis evolution relies on several pathophysiological mechanisms including neuroinflammation, neurodegeneration and remyelination and repair mechanisms. The study will identify markers of disease severity in a longitudinal cohort of patients with multiple sclerosis who are siblings (both siblings having multiple sclerosis) including: biological markers (genetic, immunological and epigenetic markers, advanced MRI markers). An integrative model to predict disease progression will be proposed based on multimodal markers.

Conditions

• Multiple Sclerosis

Interventions

Type	Name	Description
OTHER	Composite severity score calculation	Neurological examination, cognitive testing, and MRI exam

Timeline

• Start date: 2018-02-06
• Primary completion: 2020-12-15
• Completion: 2026-12-01
• First posted: 2017-12-11
• Last updated: 2026-03-11

Locations

1 site across 1 country: France