NCT03366857

Effect of Supplemental Oxygen on Perioperative BNP Concentration in Cardiac Risk Patients

Effect of Supplemental Oxygen on Perioperative Brain Natriuretic Peptide Concentration in Cardiac Risk Patients - A Prospective Randomized Clinical Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 260 (actual)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The effect of supplemental oxygen on surgical site infections was already investigated in several studies before. Although, oxygen is one of the most used medical therapy in hospitalized patients, the influence on the cardiovascular system is still unknown. Available data indicate beneficial effects of supplemental oxygen on cardiovascular function. Because, no evidence exists concerning the perioperative period, it is our objective to investigate supplemental oxygen in cardiac risk patients undergoing major abdominal surgery. Due to the significant reduction of BNP by inhibiting sympathetic nerve activity we hypothesize that supplemental oxygen have beneficial effects in perioperative BNP release in cardiac risk patients undergoing major abdominal surgery.

Conditions

• Supplemental Oxygen
• Brain Natriuretic Peptide
• Cardiac Risk Patients
• Perioperative

Interventions

Type	Name	Description
DRUG	Oxygen 30 %	The oxygen concentration will be set at 30%.
DRUG	Oxygen 80 %	The oxygen concentration will be set at 80%.

Timeline

• Start date: 2017-12-01
• Primary completion: 2019-12-31
• Completion: 2020-05-30
• First posted: 2017-12-08
• Last updated: 2020-06-11

Locations

1 site across 1 country: Austria