NCT03365752

Chloroprocaine Spinal for Outpatient Knee Surgery

A Comparison Study to Facilitate Earlier Discharge: Spinal Versus General Anesthesia for Outpatient Knee Surgeries, a Randomized Controlled Study

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 39 (actual)
• Sponsor: Hospital for Special Surgery, New York · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Outpatient knee surgeries with duration of less than one hour pose a challenge to the use of spinal anesthesia given that traditional agents remain in effect for 2-3 hours, thus creating a mismatch between length of surgery and anesthetic resolution. The investigators hypothesize that the use of chloroprocaine can combine the benefits of a short spinal anesthetic while avoiding the side effects of a general anesthetic, thus promoting earlier discharge.

Conditions

• Knee Arthroscopy

Interventions

Type	Name	Description
DRUG	Chloroprocaine	A spinal anesthetic with 2% chloroprocaine (2cc or 40 mg) will be performed
DRUG	Mepivacaine	A spinal anesthetic with 1.5% Mepivacaine (3cc or 45 mg) will be performed
DRUG	General Anesthetics	General anesthetics will be administered intravenously

Timeline

• Start date: 2018-06-24
• Primary completion: 2021-02-04
• Completion: 2021-02-04
• First posted: 2017-12-07
• Last updated: 2022-04-20
• Results posted: 2022-04-20

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study