NCT03365141

Efficacy of Intralesional Triamcinolone Injection in the Treatment of Vitiligo

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: The Catholic University of Korea · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

A randomized split-body pilot study was planned to confirm efficacy of intralesiona triamcinolone injection in patients with vitiligo

Detailed description

Intralesional corticosteroid injections have been a long-standing treatment for refractory vitiligo, with some patients showing significant improvement without surgical intervention. The investigators will perform a randomized split-body pilot trial to test the exact efficacy of intralesional triamcinolone injections. The paired symmetric vitiliginous lesions will be randomized to either control or injection groups. All lesions will be treated with narrowband UV-B phototerapy or excimer laser weekly and twice daily application of topical tacrolimus ointment for a total of 12-week period. Intralesional injections of 0.4mg/cc triamcinolone once a week are given to the experimental group. The degree of repigmentation will be assessed as % from baseline.

Conditions

• Vitiligo
• Treatment
• Intralesional Injection
• Corticosteroid

Interventions

Type	Name	Description
DRUG	Triamcinolone acetonide 0.4mg/cc	* Intralesional injection of dilute triamcinolone acetonide with 2% lidocaine (400mg/20 mL) would be performed to reduce pain when injecting the drug. * Once weekly, for a total of 12 weeks
DEVICE	Phototherapy (NBUVB or excimer laser)	NBUVB or excimer laser treatment weekly
DRUG	Topical tacrolimus	Application of topical tacrolimus ointment twice a day

Timeline

• Start date: 2017-11-14
• Primary completion: 2018-09-15
• Completion: 2018-09-15
• First posted: 2017-12-07
• Last updated: 2017-12-07

Locations

1 site across 1 country: South Korea