NCT03363425

Effect of Perioperative iv Dexmedetomidine vs. Lidocaine on Postoperative Pain, Analgesic Consumption and Recovery After Abdominal Gynaecological Surgery

Effect of Perioperative Intravenous Infusion of Dexmedetomidine vs. Lidocaine on Postoperative Pain, Analgesic Consumption, Bowel Function and Recovery After Abdominal Gynaecological Surgery: a Randomised Double Blind Study

• Status: Unknown
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University of Athens · Academic / Other
• Sex: Female
• Age: 30 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Postoperative pain continues to be inadequately managed and is the most common reason for the delay in discharge and unplanned hospital admission after surgery. Opioids remain the mainstay for postoperative analgesia. However, there is a continuous search for adjuvant therapies to reduce the doses of opioids and their related adverse effects, and extend the use of non-opioid analgesia for acute pain after abdominal surgery, thereby improving patient recovery. Currently there are no clinical trials that investigate the effect of intravenous lidocaine vs dexmedetomidine on postoperative pain, analgesic consumption and bowel function of patients undergoing abdominal gynaecological surgery. Purpose of this prospective double blind randomised clinical trial is the investigation of the effect of perioperative intravenous infusion of lidocaine vs dexmedetomidine vs placebo (Normal Saline 0,9%) on analgesic parameters and functional recovery of patients undergoing abdominal gynaecological surgery.

Conditions

• Hysterectomy
• Myomectomy

Interventions

Type	Name	Description
DRUG	Lidocaine Iv	Lidocaine Iv
DRUG	Dexmedetomidine	dexmedetomidine iv
DRUG	Normal saline	placebo

Timeline

• Start date: 2017-11-14
• Primary completion: 2018-11-01
• Completion: 2018-11-01
• First posted: 2017-12-06
• Last updated: 2017-12-08

Locations

1 site across 1 country: Greece