NCT03362827

Assessment of LTP-like Pain Amplification in Chronic Low Back Pain Patients

Assessment of Long-term Potentiation (LTP)-Like Pain Amplification in Chronic Low Back Pain Patients

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Peking University People's Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The present study is aimed to assess the LTP-like pain amplification in chronic low back pain patients to explore the central and peripheral effect for pain LTP.

Detailed description

This study is a cross-sectional study. Two groups, including low back pain group and healthy subjects group will be arranged in this study. 50 subjects will be recruited in each group, The healthy subjects were matched for sex and age in relation to the low back pain group. Conditioning electrical stimulation (100 Hz, repeated 5 times with 10 s intervals, 500 impulses) using circular pin electrodes will be used in both groups to induce LTP-like pain amplification. The pain intensity changes to pinprick and light touch stimuli will be compared between two groups.

Conditions

• Low Back Pain

Interventions

Type	Name	Description
OTHER	Chronic low back pain patients	People must have experienced low back pain for at least 3 months and have reported a minimal pain level of 30 (pain threshold) on the 0-100 pain numerical rating scale (NRS) in the last 7 days.
OTHER	Subjects without chronic low back pain	These participants must not have presented episodes of low back pain for more than 7 days in the last 12 months.

Timeline

• Start date: 2018-03-01
• Primary completion: 2018-12-31
• Completion: 2018-12-31
• First posted: 2017-12-05
• Last updated: 2017-12-05