NCT03358823

Study on the Brain Network of Angelman Syndrome

Study on the Brain Network of Angelman Syndrome Based on Multi-modal Brain Image and Neural-EEG Data

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 150 (actual)
• Sponsor: Fudan University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The aims of study on Angelman syndrome: 1. Establish the Angelman syndrome database 2. Explore the brain Network of Angelman Syndrome Based on Multi-modal Brain Image and Neural-EEG Data

Detailed description

1. The participants recruitment: from Chinese Angelman Syndrome Patients group (Angelhome : [e-mail]) and Children's Hospital of Fudan University. 2. Fistly all participants had clinically and molecularly confirmed as Angelman syndrome . All participants should entry the online questionnaries and carified by telephone or on site . All the information will be recorded in the Angelman syndrome database. Investigators will analyze and summarize the relationship of phenotype and genotype(n=200). 3. Participants who assigned the informed consent and will undergo the brain MRI inspection and Neural-EEG recording in the Children's Hospital of Fudan University. The healthy age- and sex-matched control participants will enrolled in the same hospital. The Investigators will explore the brain morphology and electrophysiological alterations and for Angelman syndrome (AS) children among the different genotypes（n=200）.

Conditions

• Angelman Syndrome

Timeline

• Start date: 2017-05-20
• Primary completion: 2019-05-20
• Completion: 2019-05-20
• First posted: 2017-12-02
• Last updated: 2021-04-26

Locations

1 site across 1 country: China