NCT03357172

Determination of Factors Involved in the Regulation of Immune Responses After Allogeneic Hematopoietic Stem Cell Transplantation

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 700 (estimated)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study concerns donors and patients receiving allogeneic stem cell haematopoietic transplantation. The aim of the study is to analyse HSC graft content in immune effector T (naive, memory, activated, exhausted) and immunoregulatory cell subtypes (Tregs, iNKT, MDSC) and correlate the results with post-transplant immune reconstitution of those different cell subtypes and clinical events (graft-versus-host-disease, relapse, infections). An ancillary study will focus on the impact of microbiota dysbiosis on post-transplant immune response and regulatory cell subsets.

Conditions

• Allogeneic Hematopoietic Stem Cell Transplantation

Interventions

Type	Name	Description
BIOLOGICAL	Blood Sample	Additional blood sample before graft, D0, D7, D15, D21, D30, D60, D90, D180, Y1, Y2
BIOLOGICAL	Bone marrow aspiration	Additional bone marrow aspiration before graft, D30, D90, Y1
BIOLOGICAL	Blood sample	Before donation
BIOLOGICAL	Allogeneic hematopoietic stem cell sample	Allogeneic hematopoietic stem cell sample

Timeline

• Start date: 2019-10-01
• Primary completion: 2026-09-30
• Completion: 2026-09-30
• First posted: 2017-11-29
• Last updated: 2019-10-14

Locations

1 site across 1 country: France