NCT03357068

Effect of Citric Acid Demineralization on Autogenous Bone Blocks Consolidation in Humans

Effect of Citric Acid Demineralization on Autogenous Bone Blocks Consolidation in Humans: Qualitative, Quantitative and Immunohistochemical Analysis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: University of Sao Paulo · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates the effect of citric acid demineralization in autogenous bone blocks consolidation. Half of participants will receive citric acid treatment at the bone block and recipient site. Other half will receive no demineralization treatment.

Detailed description

Autogenous bone grafts are indicated in areas where there is not enough bone height and/or width for implant installation. Treatment of bone surfaces with citric acid, promote a slight demineralization on surface that mimic natural processes of bone demineralization by osteoclasts. Thus, this treatment could accelerate the process of autogenous bone block consolidation to its recipient site.

Conditions

• Alveolar Bone Atrophy
• Bone Resorption

Interventions

Type	Name	Description
PROCEDURE	Control	Control side will receive only perforations on recipient site, which is the conventional technique for bone blocks graft.
PROCEDURE	Acid	Test side will receive treatment with citric acid (10%) for 30s at bone block surface and recipient site

Timeline

• Start date: 2017-07-01
• Primary completion: 2018-07-30
• Completion: 2018-12-22
• First posted: 2017-11-29
• Last updated: 2023-02-27

Locations

1 site across 1 country: Brazil