Trials / Completed
CompletedNCT03350685
Detection and Characteristic of Whipple Diseases in the Great Britany
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 267 (actual)
- Sponsor
- University Hospital, Brest · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Whipple's disease is a chronic systemic infection caused by ubiquitous bacterium Tropheryma wipplei on a genetic predisposition which should be considered in patients with recurrent episodes of seronegative arthritis, erosive or not, or inflammatory low back pain, chronic diarrhea, persistent fever, unexplained neurological signs, uveitis, endocarditis, and epithelioid granuloma. Laboratory tests may show malabsorption, erythrocyte sedimentation rate and C-reactive protein elevation, anemia, thrombocytosis, eosinophilia and lymphopenia. None of theses findings is specific and most patients have arthritis or low back pain mimicking rheumatoid arthritis and spondyloarthritis. As the disease is rare, chance for positive polymerase chain reaction testing for Tropheryma whipplei is low in this context.
Conditions
Timeline
- Start date
- 2017-11-15
- Primary completion
- 2018-02-09
- Completion
- 2018-02-09
- First posted
- 2017-11-22
- Last updated
- 2018-02-13
Locations
8 sites across 1 country: France
Source: ClinicalTrials.gov record NCT03350685. Inclusion in this directory is not an endorsement.