NCT03348280

Vitamin D and Immune Mechanisms of Hypertension in Type 2 Diabetics

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 25 Years – 80 Years
• Healthy volunteers: —

Summary

This trial will evaluate whether a particular type of circulating white blood cell, monocytes, from type 2 diabetics with high blood pressure and vitamin D deficiency vs. sufficiency will induce hormones that increase blood pressure.

Detailed description

More than half of patients with type 2 diabetes mellitus develop hypertension, which doubles their risk for cardiovascular disease. Inflammation plays a role in the development of these diseases, and monocytes, a type of white blood cell, may be critical. This study will isolate monocytes from blood samples of patients with type 2 diabetes and high blood pressure who have either high levels of vitamin D or low levels of vitamin D, and determine what their effects are on stimulating production in kidney cells of a hormone that increases blood pressure.

Conditions

• Diabetes Mellitus, Type 2
• Hypertension
• Vitamin D Deficiency

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Blood draw	Blood will be drawn to isolate monocytes after 2 weeks off of blood pressure lowering medications.

Timeline

• Start date: 2017-09-01
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2017-11-20
• Last updated: 2025-12-24

Locations

2 sites across 1 country: United States