NCT03348241

Using Gum Arabic for Cancer Patients to Protect From Oral Mucositis Caused by Chemotherapy: ِِِAn Experimental Study

Randomized Controlled Trial on the Effect of Gum Arabic to Reduce Incidence of Oral Mucositis Induced by Chemotherapy for Cancer Patients

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 386 (actual)
• Sponsor: University of Science and Technology, Yemen · Academic / Other
• Sex: All
• Age: 14 Years – 83 Years
• Healthy volunteers: Not accepted

Summary

This study was designed to investigate the effect of Gum Arabic (GA) on cancer patients to prevent chemotherapy-induced oral mucositis. Cancer patients who will receive chemotherapy were divided into two groups; study "Gum Arabic" group (which received GA with chemotherapy) and control group (chemotherapy alone); and the participants were recruited to reach 190 patients in the study group and 184 patients in control group. This clinical trial was conducted in outpatient chemotherapy sections at Radiation and Isotopes Center of Khartoum. This study was designed to test the theory that say the chemotherapy-induced oral mucositis will significantly decrease after ingestion 30 grams as daily dose of Gum Arabic in a form of solution for six weeks during therapy.

Conditions

• Chemotherapy-induced Oral Mucositis

Interventions

Type	Name	Description
DRUG	Gum Arabic	Gum acacia, also known as Gum Arabic is exuded from acacia trees; mainly from Acacia Senegal (gum Hashab or Kordofan gum) which was used in this study.
DRUG	Chemotherapy	Patients of control group and study group (Gum Arabic group) received chemotherapy according to type and stage of cancer.
BEHAVIORAL	Lifestyle counseling	Lifestyle counseling pertaining to the optimal nutrition and daily routine for oral hygiene.

Timeline

• Start date: 2015-10-26
• Primary completion: 2016-08-01
• Completion: 2016-08-01
• First posted: 2017-11-20
• Last updated: 2017-11-20