NCT03343899

Genotype-related Molecular Targets in the Vitamin D Pathway for Spinal Disc Diseases

Identification of Genotype-related Molecular Targets in the Vitamin D Pathway for Personalized Pharmacological Treatments of the Spinal Disc Diseases

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 15 (estimated)
• Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The objective of our study will be to analyze the interplay between particular VDR variants and its ligand in cells obtained from intervertebral disc and cartilage endplate and their action on cell proliferation and phenotype maintenance. The identification of novel molecular targets in the vitamin D pathway, potentially promoting pathological alterations of the tissues involved in spinal disc diseases, will allow to develop innovative and more personalized preventive and pharmacological/nutritional therapies.

Conditions

• Intervertebral Disk Degeneration

Timeline

• Start date: 2016-02-17
• Primary completion: 2018-02-17
• Completion: 2019-02-17
• First posted: 2017-11-17
• Last updated: 2017-11-17

Locations

1 site across 1 country: Italy