NCT03339180

Cardiac Injury in Patients With Influenza

Prevalence and Prognostic Implications of Cardiac Injury in Patients With Influenza-like Illness

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 466 (estimated)
• Sponsor: Örebro University, Sweden · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study investigate the prevalence of elevated biomarkers of cardiac injury in patients with suspected influenza infection and the prognostic implication on the composite endpoint of death of any cause, hospitalization due to myocardial infarction, unstable angina, heart failure and stroke.

Detailed description

The relationship between influenza and cardiovascular events was described in an early study of influenza epidemics from 1915 to 1929 including the 1918-1920 pandemic. Retrospective studies have shown increased risk for acute myocardial infarction (AMI) during the first week following an infection with influenza. Biochemical markers of cardiac injury such as high sensitive cardiac troponins may be increased during infection with influenza. Increased levels of cardiac troponins are associated with adverse outcome in many different populations.

Conditions

• Influenza, Human
• Myocardial Injury

Timeline

• Start date: 2017-10-01
• Primary completion: 2022-04-30
• Completion: 2023-12-31
• First posted: 2017-11-13
• Last updated: 2022-09-21

Locations

1 site across 1 country: Sweden