NCT03338985

Role of Senescence in the Development of Endometrial Cancer

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 140 (estimated)
• Sponsor: CHU de Reims · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Several molecular studies showed chromosomal alterations in patients with endometrial cancer, with gains in 1q, 19p, 19q, 8q, 10q and 10p and loss of 4q, 16q and 18q. Several genes of interest have been identified (P53, PTEN, PIK3CA, ß-catenin, K-ras ...). A study has already been carried out at the Reims University Hospital with inclusion of patients with endometrial cancer and patients with endometrial hyperplasia. It identified specific alterations of nosologic continuum of pathology and characterize areas of interest on the genome.

Detailed description

make a pangenomic investigation of genetic abnormalities in atypical endometrial hyperplasia and endometrial cancers.

Conditions

• Endometrial Hyperplasia and Endometrial Cancers

Interventions

Type	Name	Description
GENETIC	Genetic analysis	Genetic analysis of the samples taken during the surgery (hysterectomy or curettage resection) using CGH array technique.

Timeline

• Start date: 2017-10-16
• Primary completion: 2019-10-16
• Completion: 2020-04-16
• First posted: 2017-11-09
• Last updated: 2018-01-05

Locations

1 site across 1 country: France