NCT03336801

The Effect of Propofol or Sevoflurane on Renal Function

The Effect of Propofol and Sevoflurane Anesthesia on Renal Function in Patients Undergoing Back Surgery

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 37 (actual)
• Sponsor: Uppsala University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study investigates the role of the anesthetic agents propofol and sevoflurane on renal function in otherwise healthy patients undergoing basic back surgery.

Detailed description

Water-sodium homeostasis is central for anyone undergoing surgery, and can therefore affect surgical outcome, level of postoperative care and the length of hospital stay. Too much or too little fluid during surgery can affect the patients negatively. The kidneys play an imperative role in the regulation of water and sodium homeostasis, however there are lack of knowledge in how the anesthesia per se affects renal function. Previous studies have shown that volatile anesthetic agents such as sevoflurane can cause fluid retention. Why this happens is not completely known. We are now investigating the different affects of sevoflurane and propofol anesthesia on renal function in patients undergoing basic back surgery to elucidate if there is a difference in the risk of developing acute kidney injury.

Conditions

• Acute Kidney Injury
• Anesthesia

Interventions

Type	Name	Description
PROCEDURE	Back Surgery	All patients undergo basic back surgery.
DRUG	Propofol	Anesthesia on propofol alone.
DRUG	Sevoflurane	Anesthesia on sevoflurane alone.

Timeline

• Start date: 2017-09-01
• Primary completion: 2020-01-10
• Completion: 2020-01-10
• First posted: 2017-11-08
• Last updated: 2021-04-02

Locations

1 site across 1 country: Sweden